Mounjaro (tirzepatide) shows important weight loss results in studies on humans. https://discreetpeople.com/blog/mounjaro-tirzepatide-weight-loss-guide People who took the drug dropped 15 percent to over 20 percent of their body weight over about 72 weeks. This result occurs when they also alter their diet and activity. However, people often put the weight back on when they stop the drug. New reports from trials such as SURMOUNT-4 show that 82.5 percent of people put back at least 25 percent of the weight they lost within one year after stopping the treatment. This weight gain often undoes the good effects on heart and metabolism.