Thrombocytopenia remains a common and challenging condition in the management of hematologic disorders and complications associated with chronic liver disease. It not only significantly increases the risk of bleeding but may also delay essential surgical or invasive procedures, thereby adversely affecting patient outcomes.
Avatrombopag, a next-generation oral thrombopoietin receptor agonist (TPO-RA), offers a novel and effective solution through its distinctive mechanism of action and strong clinical performance. In parallel, DengyueMed actively supports the clinical adoption and global accessibility of such innovative therapies.



Mechanism of Action: Precisely Replicating Physiological Platelet Production
Avatrombopag selectively binds to the c-Mpl receptor expressed on hematopoietic stem cells and megakaryocytes, closely mimicking the biological function of endogenous thrombopoietin. This targeted interaction promotes megakaryocyte proliferation, differentiation, and maturation, ultimately leading to a physiological and sustained increase in platelet production.

Compared with traditional platelet transfusion, this strategy of stimulating endogenous platelet generation avoids risks such as immune reactions and infection transmission, while providing more stable and durable platelet responses—making it particularly suitable for long-term disease management.

As a second-generation TPO-RA, Avatrombopag does not interact with multivalent dietary cations such as calcium or iron, allowing administration with food. This feature significantly enhances treatment convenience and patient adherence, an advantage widely recognized in clinical practice.

Clinical Indications: Targeting Key Populations and Expanding Therapeutic Scope
The clinical utility of Avatrombopag has been clearly defined and continues to expand. It has been approved in multiple countries and regions for two primary patient populations:

Patients with chronic immune thrombocytopenia (ITP), including adults who are refractory to or intolerant of conventional therapies such as corticosteroids and immunoglobulins, as well as pediatric patients aged one year and older

Adult patients with chronic liver disease complicated by thrombocytopenia, for increasing platelet counts prior to elective procedures and reducing perioperative bleeding risk

Clinical data indicate that in chronic liver disease, dose-adjusted regimens based on baseline platelet counts (40 mg or 60 mg once daily for five consecutive days) can effectively raise platelet levels when initiated 10–13 days before surgery, substantially reducing the need for perioperative platelet transfusions.

In long-term management of ITP, Avatrombopag has demonstrated the ability to maintain platelet counts above 50 × 10⁹/L in more than 60% of patients, significantly lowering the incidence of bleeding events such as ecchymosis and epistaxis. Ongoing studies are also exploring its potential in chemotherapy-induced thrombocytopenia, myelodysplastic syndromes, and other hematologic conditions, highlighting its promising future clinical value.

Treatment Advantages: Predictable Safety and Improved Patient Experience
Safety, tolerability, and convenience represent key strengths of Avatrombopag. Long-term clinical studies have shown a favorable safety profile, with commonly reported adverse events—including headache, fatigue, nausea, and peripheral edema—generally mild to moderate and manageable.

Importantly, Avatrombopag has not demonstrated significant hepatotoxicity, a critical consideration for patients with underlying liver dysfunction. Flexible dosing adjustments based on platelet response, combined with oral administration and the absence of dietary restrictions, further reduce treatment burden and support sustained therapy.

Conclusion: Redefining Thrombocytopenia Management for Broader Patient Benefit
As a major advancement in thrombocytopenia treatment, Avatrombopag is reshaping clinical practice with its combination of oral convenience, proven efficacy, and well-controlled safety profile. From preoperative platelet optimization in chronic liver disease to long-term maintenance therapy in ITP, it delivers tailored solutions across diverse patient populations, ultimately improving quality of life and clinical prognosis.

With continued clinical research, growing real-world experience, and the support of platforms such as DengyueMed in drug accessibility and clinical education, Avatrombopag is poised to benefit an expanding number of patients and provide stronger, more reliable support for thrombocytopenia management worldwide.